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(1996) Neocortical Lewy body countscorrelate with dementia in the Lewy body variant of Alzheim-er’s disease.
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This dogma has been signicantly re-visited during recent years whenit was shown that inactivation of major targets of p53 involved in regulation of celldeath – Noxa and Puma, or senescence/cell cycle arrest gene p21 does not recapitu-late the cancer-prone phenotype of p53-decient mice [ 25, 42, 100].
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